Efecto de disrupción endocrina de la genisteína sobre Caenorhabditis elegans

Abstract

La genisteína es una isoflavona presente en la soya, de alto consumo en la población infantil por su uso como sucedáneo de la leche materna, sin embargo, poco se sabe acerca de los efectos a nivel endocrino. En este trabajo, Caenorhabditis elegans se utilizó como modelo para evaluar el efecto de disrupción endocrina de la genisteína a través de letalidad, crecimiento, reproducción, almacenamiento de lípidos y cambios en la expresión de genes de respuesta al estrés (hsp-3, sod-4 y gpx-4). Los resultados indicaron que, aunque la genisteína no indujo letalidad, sí promovió la reproducción, el aumento de la longitud del cuerpo, el incremento en la expresión de genes relacionados con estrés celular y estrés oxidativo y la acumulación lipídica. En conclusión, la genisteína generó efectos relacionados con el efecto de disrupción endocrina en C. elegans, muy probablemente a través de mecanismos de estrés oxidativo.

Licence

Authors should declare no conflicts of interest either for reasons of financing the project which is the result of the article; as well as intellectuals, academics, moral and investigative reasons.
The Journal of Andean Research is home to the ethical rules for publications issued by the COPE: http://publicationethics.org/resources/code-conduct

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